My father (Van Short) was a C-141 pilot for his Air Force career. I believe it's the only airframe he flew while in the Air Force. His younger brother was also in the Air Force, originally as an F-4 weapons officer then also on C-141s and then finally C-17s.

All Air Force flight crew members who fly in pressurized aircraft
            are required to go through altitude
            chamber training periodically.
            There's a good reason for this requirement. A sudden decompression at high
            altitude can be fatal to
            everyone on board. Quick crew reaction is essential.
            
            Such an occurrence may be rare,
            but it happened to Maj. Van E.
            Short, aircraft commander of a
            C-141B on a mission from Charleston AFB, S. C., to Ascension Island in the
            South Atlantic last October. Major Short and his Reservist
            crew are members of the 707th Military Airlift Squadron (Associate)
            based at Charleston. The flight crew
            that day consisted of Maj. Richard
            E. Gurrieri, flight examiner pilot; 2d
            Lt. Paul V. Rancatore, copilot;
            CMSgt. Richard R. Fuller, flight engineer flight examiner;
            MSgt. Richard D. Williams, instructor flight examiner;
            TSgt. Benson S. Futrell,
            flight engineer; TSgt. Anthony R.
            Reyes, flight engineer; SSgt. Rex L.
            Litchfield, loadmaster; and SSgt.
            William L. Morris, loadmaster.
            Also on board were fourteen passengers.
        

While cruising at 37,000 feet at
            night over the Atlantic between
            Antigua and Ascension, the aircraft
            encountered severe clear-air turbulence. After a violent downward
            jolt, the No. 1 engine compressor
            stalled. The aircraft yawed to the
            left, and the No. 4 engine also
            stalled. A few seconds later, the No.
            2 emergency hatch blew out, filling
            the cargo compartment with fog,
            debris, and horrendous noise. The
            escape ladder was sucked out, damaging the fuselage and vertical stabilizer as
            it flew by.
            
            The report of the ensuing few
            minutes shows the value of previous
            training for just such emergencies.
            Chief Fuller, who was sitting
            next to the flight engineer panel, felt
            that the aircraft was coming apart,
            even though the cockpit entrance
            door was closed, somewhat muffling the overall effects of the blowout.
            Sergeant Williams, who had
            been asleep in the crew loft just forward of the blown hatch, was dazed
            but managed to climb down to the
            cockpit before becoming incoherent and passing out. The crew
            quickly found out that during a
            rapid decompression, their time of
            useful consciousness without pressurized oxygen was only about
            seven seconds.
            
            The pilots donned their masks,
            pulled the engines to idle, and began
            a descending right turn. The pilot
            and flight engineer completed the
            rapid-decompression checklist,
            while the copilot attempted to contact [control centers] to declare an
            emergency in uncontrolled airspace. There was no response.
            Chief Fuller was pinned down by
            Sergeant Williams, but managed to
            reach another mask and used force
            to hold it to Williams's face until he
            recovered. At the same time, Sergeant Reyes,
            the student flight engineer, administered oxygen to a
            passenger in the jump seat who had
            become unconscious.
            
            Meanwhile, Sergeant Morris, one
            of the loadmasters, had passed out
            on the cargo floor, and the passengers
            seated in the cargo compartment were
            having life-threatening
            problems. Some couldn't reach
            their oxygen masks; some couldn't
            get a good facial fit and were losing
            vital pressure.
            
            Sergeant Williams began filling
            portable oxygen bottles with which
            Chief Fuller and Sergeant Litchfield
            tended passengers. Some were panicking;
            three were slumped in their
            seats; two more had passed out on
            the cargo deck, one of them in
            convulsions.
            
            Major Short left the
            flight deck with Major Gurrieri at
            the controls and helped Sergeant
            Morris recover. He then assisted the
            fourteen passengers until all were
            sitting up and giving the "thumbs
            up" sign.
            When the aircraft leveled off at
            10,000 feet, the copilot radioed Ascension
            Island and notified controllers that the
            aircraft was returning to
            Antigua, where Major Gurrieri
            made the landing. As the report
            states matter-of-factly, "As a result
            of the crew's quick actions, no casualties or injuries resulted."